Another trend in the field is the desire to decrease the use of steroids and calcineurin inhibitors with the majority of physicians reporting a high desire to minimize use and approximately 15 percent reporting a decrease in their use of steroids in the past year. The desire to minimize the use of calcineurin inhibitors (CNI) could be positive for Bristol-Myers Squibb if belatacept, currently under FDA review, is approved, as CNI avoidance is the greatest perceived advantage of the product. While the majority of those who are relatively familiar with the product expect at least some use, there are safety and dosing concerns that the company will have to overcome. While many physicians are still relatively unfamiliar with newcomer Zortress (everolimus) from Novartis, an increase in market share, as well as in the user base, is expected in the next six months.
Early in development, there is a high amount of expression of T-type calcium channels . During maturation of the nervous system, the expression of N or L-type currents becomes more prominent.  As a result, mature neurons express more calcium channels that will only be activated when the cell is significantly depolarized . The different expression levels of low-voltage activated (LVA) and high-voltage activated (HVA) channels can also play an important role in neuronal differentiation . In developing Xenopus spinal neurons LVA calcium channels carry a spontaneous calcium transient that may be necessary for the neuron to adopt a GABAergic phenotype as well as process outgrowth .