QNASL Nasal Aerosol is a pressurized, nonaqueous solution in a metered-dose aerosol device intended ONLY for intranasal use. It contains a solution of beclomethasone dipropionate in propellant HFA-134a (1,1,1,2-tetrafluoroethane) and dehydrated ethanol. QNASL 40 mcg Nasal Aerosol delivers 40 mcg of beclomethasone dipropionate from the nasal actuator and 50 mcg from the valve. QNASL 80 mcg Nasal Aerosol delivers 80 mcg of beclomethasone dipropionate from the nasal actuator and 100 mcg from the valve. Each strength delivers 59 mg of solution from the valve with each actuation. Each canister of QNASL 40 mcg or 80 mcg Nasal Aerosol, contains g of drug and excipients and each provides 120 actuations after priming. Additionally, QNASL 40 mcg Nasal Aerosol contains g of drug and excipients and provides 60 actuations after priming.
1. Remove blue cover.
2. Hold the base firmly and turn the mouthpiece in the direction of the arrow.
3. A recess (shaped to match the capsule) will now be visible in the base. Place capsule into the recess.
4. Return mouthpiece to original position.
5. Keep inhaler upright and firmly squeeze the two blue buttons once to puncture the capsule. Release buttons.
6. Breathe out to the side, away from the Aerolizer.
7. Place mouthpiece between the teeth and close lips firmly around it. Tilt head slightly back.
8. Breathe in deeply and steadily.
9. Remove Aerolizer from mouth and hold the breath for as long as possibleat least 10 seconds.
10. Breathe out slowly.
11. To take a second dose, open the inhaler, remove the empty capsule and repeat steps 3-8.
12. Replace cover on Aerolizer.
One of the most crucial components of a MDI is its propellant. The propellant provides the force to generate the aerosol cloud and is also the medium in which the active component must be suspended or dissolved. Propellants in MDIs typically make up more than 99% of the delivered dose,  so it is the properties of the propellant that dominate more than any other individual factor. This is often overlooked in literature and in industry because so few propellants are used and their contribution is often taken for granted. Suitable propellants must pass a stringent set of criteria, they must: