Concommitent drug intake should be carefully scrutinized prior to prescribing or injecting a corticosteroid. A number of drug interactions have been reported that often potentiate or diminish the drugs clearance and half-lives. Non-steroidal anti-inflammatory drugs, oral contraceptives and other exogenous estrogens are known to increase the potency of corticosteroids. Macrolide antibiotics such as erythromycin and azithromycin may increase the potency of methylprednisolone by decreasing its clearance. In contrast rifampin, phenobarbital, carbamazepine, and phenytoin often increase drug clearance and decrease the anti-inflammatory effect of the corticosteroid. Oral anti-coagulants and theophylline have varying effects. 15 The physician would be prudent in making doseage adjustments accordingly when patients are discovered to be consuming these drugs.
It is important to use the correct amount of topical steroid for your eczema, as instructed by your healthcare professional. Topical steroids should be applied with clean hands so that the skin just glistens. It can sometimes be difficult to judge how much steroid to use and there are guidelines on the amount required to cover body areas that are affected by eczema. These are based on the Finger Tip Unit (FTU), and explained in detail in our fact sheet which you can download as a pdf from the related documents to the right of this page.
Corticosteroids have been used to control MS relapses for decades. Data on the effectiveness of these medications in MS comes from four randomized, placebo-controlled studies of intravenous and oral methylprednisolone. Altogether, these studies included 74 people with MS who received corticosteroid treatment and 66 who received placebo. Corticosteroid treatment with methylprednisolone resulted in greater speed of recovery from exacerbation compared with placebo. However, treatment did not decrease the risk of future relapses or decrease the progression of disability.