Corticosteroids do not always adequately improve polymyositis. In these patients, immunosuppressive medications are considered. These medications can be effective by suppressing the immune response that attracts the white blood cells of inflammation to the muscles. Many types are now commonly used and others are still experimental. Methotrexate ( Rheumatrex , Trexall ) can be taken by mouth or by injection into the body. Azathioprine (Imuran) is an oral drug. Both can cause liver and bone-marrow side effects and require regular blood monitoring. Cyclophosphamide ( Cytoxan ), chlorambucil ( Leukeran ), and cyclosporine ( Sandimmune ) have been used for serious complications of severe disease, such as scarring of the lungs ( pulmonary fibrosis ). These also can have severe side effects which must be considered with each patient individually. Treatment with intravenous infusion of immunoglobulins (IVIG) has been shown to be effective in severe cases of polymyositis that are resistant to other treatments. Recent research reports indicate that intravenous rituximab ( Rituxan ) may be helpful in treating resistant disease.
Just like it is impossible to run a marathon without some sort of training (at least for most people!) doing Bikram Yoga operates along the same principle, as, for that matter, any kind of sport or physical activity: you get better over time through regular and committed repetition. Additionally, BY postures were specifically designed by Bikram to help him combat pain from a physical injury. So if it worked for him (and me!), I’m sure it can and will do a lot of good for all of us pain-sufferers – eventually, of course, – if we keep up with it till we master each posture! Indeed, the pain almost starts dissipating within the first few sessions of BY! Just do each posture the best you can until you get there, as you almost certainly will!
Other athletes, including Joaquim Cruz and Ben Johnson, expressed disbelief over Griffith Joyner's dramatic improvement over a short period of time.  Before the 1988 track and field season, Griffith Joyner's best time in the 100-meter sprint was seconds. In 1988, she improved that by seconds (or sec for the non-wind-aided time). Similarly, her best before 1988 at 200-meters was seconds. In 1988, she improved that by seconds to seconds, another time that has not been approached. Griffith Joyner attributed the change in her physique to new health programs.  Al Joyner replaced Bob Kersee as her coach, and he changed her training program to include more lower body strength training exercises such as squats and lunges.