At the Dentist
Before dental treatment that might cause bleeding, hemophiliacs may need extra blood products (factor-replacement therapy). This will increase the amount of clotting factor in the blood. If you need blood products or proteins for dental procedures, you may need to have your treatment in a hospital. However, some people can administer the blood products themselves. Talk to your physician and dentist about your condition. You may need to have blood tests before treatment. These tests will show the levels of blood proteins and show if you are at risk for uncontrolled bleeding.
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
Kidney function: Long-term use of naproxen may lead to a higher risk of reduced kidney function. If you have kidney disease, liver disease, or heart failure; take diuretics (water pills); or are a senior; you have an increased risk for kidney problems while taking this medication. If you are taking medications such as diuretics (., hydrochlorothiazide, triamterene, indapamide), ACE inhibitors (., enalapril, ramipril), angiotensin receptor blockers (., valsartan, candesartan), or cyclosporine, you are also at an increased risk.