Oxidation of glucose catabolic or anabolic

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  • Circulating glucose concentrations do not drop below  mmol L −1 even in prolonged starvation.
  • During starvation, the brain must be supplied with fuel in the form of glucose or ketone bodies.
  • Carbohydrate reserves are depleted after 24 h of starvation.
  • In prolonged starvation, gluconeogenesis provides the glucose oxidised by the brain.
  • The major substrates for gluconeogenesis are amino acids derived from skeletal muscle protein breakdown.
  • Circulating ketone body concentrations rise during prolonged starvation.
  • During starvation, most tissues utilise fatty acids and/or ketone bodies to spare glucose for the brain.
  • Glucose utilisation by the brain is decreased during prolonged starvation as the brain utilises ketone bodies as the major fuel.
  • High concentrations of ketone bodies result in significant excretion of ketones.
  • Urinary ketones are excreted as ammonium salts derived from the renal metabolism of glutamine with the carbon skeleton being recovered through renal gluconeogenesis.

Oxidation of glucose catabolic or anabolic

oxidation of glucose catabolic or anabolic

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