Saponin steroid

Long before the era of high-throughput screening and genomics, drug discovery relied heavily on natural compounds. In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.

Saponins from the Gypsophila paniculata (baby’s breath) plant have been shown to significantly augment the cytotoxicity of immunotoxins and other targeted toxins directed against human cancer cells. The research groups of Professor Hendrik Fuchs ( Charité University, Berlin, Germany) and Dr David Flavell (Southampton General Hospital, United Kingdom) are working together toward the development of Gypsophila saponins for use in combination with immunotoxins or other targeted toxins for patients with leukaemia , lymphoma and other cancers .

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As we mentioned, fenugreek contains 4-hydroxyisoleucine, the amino acid responsible for encouraging the production of insulin and lowering the rate of glucose assimilation in the intestines.  This can be of particular benefit to those with diabetes for stabilizing blood sugar levels.

In one study , using the amino acid extracted from fenugreek seeds, it was concluded that "4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' anti-diabetic properties." 

In addition, the presence of galactomannan in fenugreek furthermore slows down the rate of blood sugar absorption.  The sprouts or seeds can therefore be added to meals as a potentially effective way to prevent blood sugar spikes from high glycemic foods.

The diosgenin compound has been shown to help reduce the level of serum cholesterol.  In addition, other saponins and extra components like polysaccharides, pectin, hemicellulose and mucilage are found to help lower the "bad" cholesterol (LDL) by binding to and eliminating toxins while inhibiting bile salts from being absorbed in the colon. 

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Saponin steroid

saponin steroid

As we mentioned, fenugreek contains 4-hydroxyisoleucine, the amino acid responsible for encouraging the production of insulin and lowering the rate of glucose assimilation in the intestines.  This can be of particular benefit to those with diabetes for stabilizing blood sugar levels.

In one study , using the amino acid extracted from fenugreek seeds, it was concluded that "4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' anti-diabetic properties." 

In addition, the presence of galactomannan in fenugreek furthermore slows down the rate of blood sugar absorption.  The sprouts or seeds can therefore be added to meals as a potentially effective way to prevent blood sugar spikes from high glycemic foods.

The diosgenin compound has been shown to help reduce the level of serum cholesterol.  In addition, other saponins and extra components like polysaccharides, pectin, hemicellulose and mucilage are found to help lower the "bad" cholesterol (LDL) by binding to and eliminating toxins while inhibiting bile salts from being absorbed in the colon. 

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